Xilinx PairHMM Genomics

PairHMM Algorithm resides in L2/tests/pairhmm_8x2 directory.

Xilinx PairHMM Algorithm is FPGA based implementation of standard PairHMM. Xilinx implementation of PairHMM application is aimed for achieving high throughput. This Xilinx PairHMM application is developed and tested on Xilinx Alveo U250.

Results

Resource Utilization

Table below presents resource utilization of Xilinx Smithwaterman Genomics kernels. The final Fmax achieved is 300MHz.

Flow LUT DSP BRAM URAM
PairHMM 66.9K 504 35 32

Performance Data

Table below presents kernel throughput achieved for a single compute unit.

Topic Results
Genomics Throughput 4.8GCups

Note: Overall throughput can still be increased with multiple compute units.

Software & Hardware

Software: Xilinx Vitis 2021.2
Hardware: xilinx_u250_gen3x16_xdma_3_1_202020_1(Xilinx Alveo U250)

Executable Usage

To execute pairHMM kernel : ./build/xil_pairhmm ./build/xclbin_<xsa_name>_<TARGET mode>/pairhmm.xclbin --syn <number of tests>

  • Note: Default arguments are set in Makefile